Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study
Authors' conclusion
Increased birth weight appears to be a risk factor for later manifestation of rheumatoid arthritis due to both fetal genetic components and high BMI persisting into adulthood.
Study context
- Population
- Genetic information of up to 806,834 participantsup to
- Participants
- 806,834 participants
- Comparison
- Genetically predicted time-varying body size from birth to adulthood and RA, psoriasis, PsA and multiple sclerosis
Methodological detailslife course, radial inverse-variance weighted approach, multivariable Mendelian randomisation (MR), sensitivity analyses
- Life course
- Radial inverse-variance weighted approach
- Multivariable MR
- Sensitivity analyses
Main finding
As reported in the abstract
Genetically predicted birth weight (fetal effect) and RA, OR
1.44
95% CI 1.17 to 1.77Padj =0.005
Further findings
Mediation of birth weight–RA association by body mass index (BMI) in adulthood (rather than childhood)
- Adult BMI, OR
- 1.45 (95% CI 1.14 to 1.84; Padj =0.019)
Direct effect of birth weight on RA after adjustment for time-varying BMI
- Attenuated, OR
- 1.19 (95% CI 0.88 to 1.62; Padj =1)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study. RMD Open. Published 14 November 2023. doi:10.
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