A bidirectional Mendelian randomisation study of the association between rheumatoid arthritis and frailty
Authors' conclusion
The present study provides evidence supporting the fact that rheumatoid arthritis can increase the prevalence of frailty.
Study context
- Population
- Europeans in large GWAS of RA and frailty index
- Comparison
- Genetically predicted RA and frailty index, in both directions
- Outcome
- Causal association of RA with frailty (frailty index)
Methodological detailsInverse variance weighted (IVW), MR-Egger and weighted median methods, MR-Egger intercept and MR-PRESSO for pleiotropy, leave-one-out analysis, validation analysis
- IVW, MR-Egger and weighted median methods
- MR-Egger intercept and MR-PRESSO for pleiotropy
- Leave-one-out analysis
- Validation analysis
Performance
As reported in the abstract
Frailty (genetically predicted RA → frailty), primary analysis
IVW OR
1.01; 95% CI 1.01-1.02
p=2.47 E-06
Further findings
Frailty (RA → frailty), validation analysis
- IVW OR
- 1.03; 95% CI 1.02-1.04; p=3.30E-17
RA (genetically predicted frailty → RA), reverse direction
- IVW β
- 1.25; SE 0.44; 95% CI 0.39-2.12; p=4.58E-03
Original publication
A bidirectional Mendelian randomisation study of the association between rheumatoid arthritis and frailty. Clin Exp Rheumatol. Published 23 July 2023. doi:10.
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