Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study
Main finding · Osteoporosis, inverse variance-weighted methodResult — go to the resultOdds ratio 1.10 95% CI 1.06–1.14Authors' conclusion
Our results show a potential causal association between genetically predicted RA and osteoporosis. The finding was consistent when we used different MR methods and the sensitivity analysis.
Study context
- Population
- Japanese populations, genome-wide association studies (GWAS) summary data from BioBank Japan: Rheumatoid arthritis (RA) (4,199 cases and 208,254 controls) and osteoporosis (7,788 cases and 204,665 controls)11 SNPs as instruments
- Comparison
- Genetically predicted RA vs no RA for osteoporosis
- Outcome
- Osteoporosis, inverse variance-weighted method
Methodological detailstwo-sample summary-level GWAS data (BioBank Japan), 11 RA-related SNPs as instrumental variables, inverse variance-weighted primary method, sensitivity analyses: MR-Egger, weighted median, weighted mode, Mendelian randomization pleiotropy residual sum and outlier (MRPRESSO)
- Two-sample summary-level GWAS data (BioBank Japan)
- 11 RA-related SNPs as instrumental variables
- Inverse variance-weighted primary method
- Sensitivity analyses: MR-Egger, weighted median, weighted mode, MRPRESSO
Main finding
As reported in the abstract
Odds ratio
1.10
95% CI 1.06–1.14
P < 0.001
Genetically predicted RAvs no RA (per genetic liability) for osteoporosis
OR 1.10 (95% CI 1.06–1.14); P < 0.001
Further findings
Osteoporosis, sensitivity analyses (other Mendelian randomization (MR) methods)
- MR-Egger's method
- OR 1.09, 95% CI 1.03-1.16, P = 0.023
- Weighted median
- OR 1.09, 95% CI 1.04-1.15, P < 0.001
- Weighted mode
- OR 1.08, 95% CI 1.03-1.13, P = 0.012
- Positive association robust
Horizontal pleiotropy (MR-Egger's intercept test or MRPRESSO test)
- Horizontal pleiotropy not detected
- P = 0.737
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study. Arthritis Rheumatol. Published 16 June 2023. doi:10.
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