Synovial and serum B cell signature of autoantibody-negative rheumatoid arthritis vs autoantibody-positive rheumatoid arthritis and psoriatic arthritis
Authors' conclusion
The synovial and serum immunophenotype indicative of B lymphocyte involvement in autoantibody-negative RA differs from that of autoantibody-positive RA and more closely resembles that observed in polyarticular PsA.
Study context
- Population
- Patients with autoantibody-positive and -negative chronic arthritides (RA, PsA) undergoing US-guided synovial biopsy
- Participants
- 131 patients
- Exposure
- Autoantibody-negative RA vs autoantibody-positive RA, polyarticular PsA and oligoarticular PsA
- Autoantibody-positive RAn = 43
- Autoantibody-negative RAn = 35
- Polyarticular PsAn = 25
- Oligoarticular PsAn = 28
- Outcome
- Synovial B lymphocyte infiltration and lympho-myeloid synovitis
Methodological detailsultrasound-guided synovial biopsies
- Ultrasound-guided synovial biopsies
Main finding
As reported in the abstract
- Synovitis scores and CD68+ sublining macrophage infiltration comparable irrespective of clinical diagnosis and disease subtype
- B cell infiltration and lympho-myeloid synovitis in autoantibody-negative RA similar to polyarticular PsA
- Oligoarticular PsA had the lowest B cell scores
- Autoantibody-negative RA vs Autoantibody-positive RA: P = 0.03
- Autoantibody-negative RA vs Autoantibody-positive RA: P = 0.07
Observational data: associations, not effects.
Further findings
Serum CXCL13
- Associated with lympho-myeloid synovitis; highest in autoantibody-positive RA, intermediate and comparable in autoantibody-negative RA and polyarticular PsA, low in oligoarticular PsA
Original publication
Synovial and serum B cell signature of autoantibody-negative rheumatoid arthritis vs autoantibody-positive rheumatoid arthritis and psoriatic arthritis. Rheumatology (Oxford). Published 22 July 2023. doi:10.
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