Lupus & antiphospholipid syndrome
Gender differences in SLE: report from a cohort of 417 Caucasian patients
Authors' conclusion
In our cohort, clinical manifestations and disease course were similar in male and female patients; however, male patients displayed higher prevalence of APS and early damage accrual probably due to the later disease onset.
Study context
- Population
- Caucasian patients with SLE with at least 1 year of follow-up, monocentric cohort51 men · 366 women
- Participants
- 417 patients
- Exposure
- Men vs women with SLE
- Menn = 51
- Womenn = 366reference
- Outcome
- Gender differences in disease course, comorbidities, use of medications and long-term outcomes
Methodological detailsretrospective gender-based analysis of prospectively collected data, monocentric, at least 1 year of follow-up
- Retrospective gender-based analysis of prospectively collected data
- Monocentric
- At least 1 year of follow-up
Main finding
As reported in the abstract
Gender differences
- Men: significantly higher median age at disease onset and diagnosis; higher prevalence of late-onset SLE, serositis at onset, antiphospholipid syndrome (APS) and mycophenolate use within the first year of disease
- Women: higher prevalence of haematological abnormalities, higher cumulative exposure to AZA and higher cumulative GC dose at 5 years
- Men: shorter time to first damage item and higher prevalence of damage at 1 and 5 years; no longer significant when late-onset patients were excluded
- No differences in childhood onset, onset-to-diagnosis delay, time to renal involvement and histology, cumulative autoantibody positivity, flares, hospitalisations, median SLE Damage Index score, type of damage, age and time to first cardiovascular event, CKD and death
Observational data: associations, not effects.
Original publication
Gender differences in SLE: report from a cohort of 417 Caucasian patients. Lupus Sci Med. Published 25 April 2023. doi:10.
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