Fibromyalgia & musculoskeletal pain
Functional Connectivity and Structural Signatures of the Visual Cortical System in Fibromyalgia: A Magnetic Resonance Imaging Study
Authors' conclusion
Altered FCs and structure in the visual cortical system might be involved in the pathomechanisms and clinical presentation in FM.
Study context
- Population
- Patients with fibromyalgia (FM) and pain-free participants
- Participants
- 26 vs 30
- Exposure
- Patients with FM vs pain-free participants
- FMn = 26
- Pain-freen = 30reference
- Outcome
- FC and cortical structure of the visual system
Methodological detailsresting-state functional MRI, seed-based functional connectivity (FC) analyses, voxel-based morphometry, surface-based morphometry
- Resting-state functional MRI
- Seed-based FC analyses
- Voxel-based morphometry
- Surface-based morphometry
Main finding
As reported in the abstract
- FM: increased FCs within visual networks; FC between visual medial network and right lingual gyrus positively correlated with Fibromyalgia Impact Questionnaire (FIQ) score
- FM: decreased FCs from the visual occipital network to several regions; FCs to bilateral frontal orbital cortices negatively correlated with FIQ and Pittsburgh Sleep Quality Index scores
- FM: cortical thickness of lateral occipital cortex, lingual gyrus and pericalcarine tended to increase
Observational data: associations, not effects.
Original publication
Functional Connectivity and Structural Signatures of the Visual Cortical System in Fibromyalgia: A Magnetic Resonance Imaging Study. J Rheumatol. Published 1 May 2023. doi:10.
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