Fibromyalgia & musculoskeletal pain
Correlation between nocturnal heart rate variability parameters and circulating neuropeptides in patients suffering from fibromyalgia
Authors' conclusion
The serum levels of beta-endorphin and neurotensin in women suffering from FM correlate with nocturnal heart rate variability parameters, revealing sympathetic hyperactivity.
Study context
- Population
- Women with fibromyalgia (FM) without comorbid conditions and matched healthy women, free from medications that could affect the autonomic nervous system
- Participants
- 23 vs 15
- Comparison
- Women with FM vs age and BMI-matched healthy women
- FMn = 23
- Healthyn = 15reference
- Outcome
- Dysautonomia-associated neuropeptide serum levels and their correlation with nocturnal heart rate variability parameters and disease severity
Methodological detailsage and BMI-matched healthy controls
- Age and BMI-matched healthy controls
Main finding
As reported in the abstract
Serum beta-endorphin
P = 0.028
Observational data: associations, not effects.
Further findings
Serum neurotensin
P = 0.016
Correlation with nocturnal R-R interval SD
- Beta-endorphin, Rho (p=0.025)
- −0.52
- Neurotensin, Rho (p=0.003)
- −0.6
Correlation with FIQR "tenderness to touch"
- Beta-endorphin, Rho (p<0.05)
- −0.49
- Neurotensin, Rho (p<0.05)
- −0.41
Original publication
Correlation between nocturnal heart rate variability parameters and circulating neuropeptides in patients suffering from fibromyalgia. Clin Exp Rheumatol. Published 13 January 2025. doi:10.
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