Fibromyalgia & musculoskeletal pain
Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine
Main finding · Any fall-related visitResult — go to the resultHazard ratio 0.52 95% CI 0.43–0.64Authors' conclusion
Compared with incident use of duloxetine, incident use of gabapentin was not associated with increased fall-related visits.
Study context
- Population
- Adults aged 65 years or older with diabetic neuropathy, postherpetic neuralgia or FM, without depression, anxiety, seizures or cancer in the prior 365 days; MarketScan commercial claims, 2014–2021median follow-up 30 days
- Participants
- 57,086 adults
- Exposure
- Gabapentin initiation vs duloxetine initiation
- Gabapentinn = 52,152
- Duloxetinen = 4,934reference
- Outcome
- Hazard of any fall-related visit after initiation until discontinuation of treatment
- Follow-up
- 6 months
Methodological detailsnew user, active comparator, target trial emulation, stabilized inverse probability of treatment weighting
- New user, active comparator
- Target trial emulation
- Stabilized inverse probability of treatment weighting
Main finding
Any fall-related visit
Hazard ratio
0.52
95% CI 0.43–0.64
Gabapentinvs Duloxetine
HR 0.52 (95% CI 0.43–0.64)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Gabapentin | Duloxetine |
|---|---|---|
| Weighted cumulative incidence of fall-related visit per 1000 person-years at 30, 90 and 180 days | 103.60, 90.44, and 84.44 per 1000 person-years | 203.43, 177.73, and 158.21 per 1000 person-years |
Severe fall-related events · 6 months
- No difference in the hazards of experiencing severe falls
Original publication
Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine. Ann Intern Med. Published 7 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →