Fibromyalgia & musculoskeletal pain
The bidirectional association between chronic musculoskeletal pain and sleep-related problems: a systematic review and meta-analysis
Pooled result · Incidence of CMPResult — go to the resultOdds ratio 1.79 95% CI 1.55–2.08Authors' conclusion
This study provides robust evidence concerning the longitudinal association between SRP and incidence-persistence of CMP in adults. In addition, the available prospective studies support the existence of a bidirectional relationship between CMP and SRP.
Study context
- Population
- Adults (aged 34.4–71.7 years) in prospective cohort studies20 studies (17 in meta-analysis)
- Participants
- 208,190 adults
- Comparison
- Sleep-related problems (SRP) vs no SRP at baseline; Chronic musculoskeletal pain (CMP) vs no CMP at baseline
- Outcome
- Prospective bidirectional associations between SRP and CMP
Methodological detailsrandom effects meta-analysis, subgroup and meta-regression analyses, MOOSE guidelines
- Random effects meta-analysis
- Subgroup and meta-regression analyses
- MOOSE guidelines
Pooled result
Incidence of CMP
Odds ratio
1.79
95% CI 1.55–2.08
P < 0.001
SRPvs No SRP
OR 1.79 (95% CI 1.55–2.08); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Persistence of CMPSRPvs No SRPI2 = 88.5% | 2.04 (1.42–2.94) | P < 0.005 | |
| Incidence of SRPCMPvs No CMPI2 = 90.0% | 2.02 (1.62–2.53) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Subgroup and meta-regression analyses (SRP and CMP)
- Longer follow-up, higher heterogeneity between studies
- No significant effect of follow-up time, sex proportion or age in meta-regression
Original publication
The bidirectional association between chronic musculoskeletal pain and sleep-related problems: a systematic review and meta-analysis. Rheumatology (Oxford). Published 27 April 2023. doi:10.
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