Fibromyalgia & musculoskeletal pain
Interleukin-1 receptor accessory protein expression could link to the insula-default mode network connection and clinical depression in fibromyalgia: a preliminary exploratory study
Authors' conclusion
IL-1RAP could modulate depression through the AI and PCC connections in FM patients.
Study context
- Population
- Fibromyalgia (FM) patients assessed clinically, by serum proteomics and brain magnetic resonance imaging (MRI)
- Participants
- 17 patients
- Outcome
- Associations among serum IL-1RAP expression, AI-DMN functional connectivity and depression (BDI-II scores)
- Follow-up
- baseline and 1-year follow-up
Methodological detailspreliminary, exploratory, baseline and 1-year follow-up, robust linear regression, ridge regression
- Preliminary
- Exploratory
- Baseline and 1-year follow-up
- Robust linear regression
- Ridge regression
Main finding
As reported in the abstract
- IL-1RAP expression significantly predicted functional connectivity (FC) between bilateral anterior insula (AI) and posterior cingulate cortex (PCC)
- Right AI-PCC FCs negatively affect BDI-II scores
- Negative effects of IL-1RAP × right AI-PCC FC interactions significant at baseline but not at 1-year follow-up
Observational data: associations, not effects.
Original publication
Interleukin-1 receptor accessory protein expression could link to the insula-default mode network connection and clinical depression in fibromyalgia: a preliminary exploratory study. Clin Exp Rheumatol. Published 25 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →