Fibromyalgia & musculoskeletal pain
Reduced Cortico‐Cortical Resting‐State Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia
Authors' conclusion
Reduced cortico-cortical sensory integration involving PCL/S1 and spanning the sensory systems may underly critical pain sensory features in youth with JFM.
Study context
- Population
- Female adolescents with juvenile-onset fibromyalgia and healthy female adolescents
- Participants
- 37 vs 43
- Exposure
- Female adolescents with juvenile-onset FM vs healthy female adolescents
- JFMn = 37
- Healthyn = 43reference
- Outcome
- Data-driven resting-state functional connectivity (rsFC) alterations and their associations with bodily pain
Methodological detailsresting-state functional MRI, whole-brain voxel-wise intrinsic connectivity contrast, seed-based analyses
- Resting-state functional MRI
- Whole-brain voxel-wise intrinsic connectivity contrast
- Seed-based analyses
Main finding
As reported in the abstract
Voxel-wise rsFC alterations, JFM vs healthy
- Reduced resting-state functional connectivity (rsFC) in paracentral lobule (PCL)/primary somatosensory cortex (S1), T = 4.89
- pFWE < 0.001
- Reduced rsFC in left midcingulate cortex, T = 4.67
- pFWE = 0.043
- Post hoc: reduced rsFC spanning major cortical sensory hubs, T > 4.4
- pFWE < 0.030
- Cortico-cortical rsFC reductions within PCL/S1 in locations innervated by bodily areas where pain was most frequent, F = 3.15
- positive false discovery rate = 0.029
- Cortico-cortical rsFC reductions within PCL/S1 predicted widespread pain, T > 4.4
- pFWE < 0.045
- Increased PCL/S1-thalamus rsFC, T = 4.75
- pFWE = 0.046
- Increased PCL/S1-anterior insula rsFC, T = 5.13
- pFWE = 0.039
Observational data: associations, not effects.
Original publication
Reduced Cortico‐Cortical Resting‐State Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia. Arthritis Rheumatol. Published 21 December 2023. doi:10.
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