Spondyloarthritis & psoriatic arthritis
Association between Patient Acceptable Symptom State and disease activity in psoriatic arthritis is disrupted by confounders, including comorbid fibromyalgia
Authors' conclusion
Our data suggest that fibromyalgia influences the patient's perception of the disease and has a negative impact on PASS status independently of disease activity, thus limiting the utility of this Patient reported outcome in real world clinical practice.
Study context
- Population
- Consecutive Psoriatic Arthritis (PsA) participants, July 2021 to November 2021
- Outcome
- Association between PASS and PsA disease activity (DAPSA), accounting for comorbid fibromyalgia
Methodological detailsmulticentre, observational, consecutive enrolment, multivariable logistic regression adjusted for fibromyalgia
- Multicentre
- Observational
- Consecutive enrolment
- Multivariable logistic regression adjusted for fibromyalgia
Main finding
As reported in the abstract
Association between PASS and DAPSA (adjusted for fibromyalgia)
- No significant association between patient acceptable symptom state (PASS) and Disease Activity for Psoriatic Arthritis (DAPSA) low disease activity, DAPSA as nominal variable (remission, low, moderate, high disease activity) or DAPSA as continuous variable
- Multivariable logistic regressions adjusted for the presence of fibromyalgia
Observational data: associations, not effects.
Original publication
Association between Patient Acceptable Symptom State and disease activity in psoriatic arthritis is disrupted by confounders, including comorbid fibromyalgia. Clin Exp Rheumatol. Published 7 February 2023. doi:10.
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