Spondyloarthritis & psoriatic arthritis
Identification of circulating microRNA patterns in patients in psoriasis and psoriatic arthritis
Authors' conclusion
miRNA signatures in PsA and PsO patients differ from controls.
Study context
- Population
- Patients with PsA, psoriasis and healthy controls; serum miRNAs, hand MRI recordeddiscovery phase 48 samples
- Participants
- 141 patients
- Comparison
- PsA vs psoriasis (PsO) vs healthy controls
- PsAn = 51
- PsOn = 40
- Controlsn = 50reference
- Outcome
- Circulating miRNA signatures associated with PsO and PsA
Methodological detailsdiscovery and validation phases, RT-qPCR serum miRNA profiling
- Discovery and validation phases
- RT-qPCR serum miRNA profiling
Main finding
As reported in the abstract
Circulating miRNA signatures
- Discovery: miRNAs down- or upregulated vs controls in PsO (adj. P < 0.05)
- 51
- Discovery: miRNAs down- or upregulated vs controls in PsA (adj. P < 0.05)
- 64
- Discovery: miRNAs changed in both PsO and PsA
- 33
- Validation: miRNAs of 17 top candidates discriminating PsA and PsO from controls (AUC ≥0.70, all P < 0.05)
- 9
- miRNAs significantly differently regulated between PsO and PsA (miR-19b-3p, miR-21-5p, miR-92a-3p, let-7b-5p)
- 4
- AUC of combination of these 4 miRNAs to discriminate PsO and PsA (multivariate regression model)
- 0.92
Observational data: associations, not effects.
Original publication
Identification of circulating microRNA patterns in patients in psoriasis and psoriatic arthritis. Rheumatology (Oxford). Published 3 February 2023. doi:10.
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