Lupus & antiphospholipid syndrome
Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis
Authors' conclusion
Our study demonstrates that fetal morbidity and severe maternal morbidity occur at a higher rate in patients with SLE compared with those without.
Study context
- Population
- All delivery-related hospital admissions in the US National Inpatient Sample, 2008 to 201740 million delivery admissions
- Exposure
- Deliveries in patients with systemic lupus erythematosus (SLE) vs deliveries in patients without SLE
- SLEn = 51,161
- Outcome
- Fetal morbidity (pre-term delivery, IUGR) and 21 indicators of severe maternal morbidity (CDC definitions)
Methodological detailsnationwide, National Inpatient Sample, sample-weighted descriptive statistics
- Nationwide
- National Inpatient Sample
- Sample-weighted descriptive statistics
Main finding
As reported in the abstract
Fetal morbidity
Intrauterine growth restriction (IUGR), SLE vs without SLE
8.0% vs 2.7%
Pre-term delivery, SLE vs without SLE
14.5% vs 7.3%
Observational data: associations, not effects.
Further findings
Severe maternal morbidity during delivery
- Blood transfusion or cerebrovascular disorder: mothers with SLE nearly four times as likely
- Acute renal failure: mothers with SLE 15 times as likely
Original publication
Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis. RMD Open. Published 25 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →