Familial Risk of Gout and Interaction With Obesity and Alcohol Consumption: A Population‐Based Cohort Study in Korea
Main finding · Risk of goutResult — go to the resultHazard ratio 2.42 95% CI 2.39–2.46Authors' conclusion
Our findings indicate the possibility of an interaction between gout-associated genetic factors and obesity/alcohol consumption.
Study context
- Population
- Individuals in the Korean National Health Insurance database, 2002 to 2018
- Participants
- 5,524,403 individuals
- Exposure
- Individuals with vs without gout-affected first-degree relatives
- Outcome
- Development of gout (familial risk)
Methodological detailsKorean National Health Insurance database, additive interaction (RERI)
- Korean National Health Insurance database
- Additive interaction (RERI)
Main finding
Risk of gout
Hazard ratio
2.42
95% CI 2.39–2.46
Family historyvs No family history
HR 2.42 (95% CI 2.39–2.46)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Gout risk with family history plus overweight or moderate alcohol consumption
| HR (95% CI) | ||
|---|---|---|
| Family history + overweight | 4.39 (4.29–4.49) | |
| Family history + moderate alcohol | 2.28 (2.22–2.35) | |
| 0.20.5125Hazard ratio (log scale) |
Additive interaction of family history with obesity/alcohol (RERI)
| RERI (95% CI) | |
|---|---|
| Overweight | 0.96 (0.85–1.06) |
| Obese | 1.88 (1.61–2.16) |
| Heavy drinkers | 0.36 (0.20–0.52) |
Gout risk with family history plus overweight or moderate alcohol consumption
- Exceeded the sum of individual risks but only statistically significant in overweight individuals
Additive interaction of family history with obesity/alcohol (RERI)
- More prominent interaction in obese and heavy drinkers, suggesting a dose-response interaction pattern
Original publication
Familial Risk of Gout and Interaction With Obesity and Alcohol Consumption: A Population‐Based Cohort Study in Korea. Arthritis Care Res (Hoboken). Published 7 March 2023. doi:10.
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