Lupus & antiphospholipid syndrome
Factors associated with cardiovascular events in systemic lupus erythematosus in a monocentric cohort with up to 40 years of follow-up
Authors' conclusion
Cardiovascular disease is highly prevalent among patients with SLE and is associated with antiphospholipid antibodies, glucocorticoid therapy, and diagnosis before 2000.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) treated at the Lupus Clinic at University College London Hospital (UCLH) between 1979 and 2020; ethnically diverse cohortmax follow-up 40 years
- Participants
- 419 patients
- Outcome
- CVE and factors associated with CVE
Methodological detailssingle-centre, multivariable regression
- Single-centre
- Multivariable regression
Main finding
As reported in the abstract
CVE in SLE: occurrence and associated factors
- Patients with at least one cardiovascular events (CVE)
- 71 (17%)
- aPL positivity associated with CVE (multivariable analysis; only factor)
- p-value<0.001
Observational data: associations, not effects.
Further findings
Factors associated with types of CVE
- aPL associated with VTE
- P < 0.001
- aPL associated with cerebrovascular events
- P = 0.007
Factors associated with CVE (dedicated subanalyses)
- Cumulative GC dose associated with CVE
- P = 0.010
- SLE diagnosis before 2000 associated with CVE
- P < 0.001
Original publication
Factors associated with cardiovascular events in systemic lupus erythematosus in a monocentric cohort with up to 40 years of follow-up. Semin Arthritis Rheum. Published 12 May 2023. doi:10.
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