Systemic sclerosis & Raynaud's
Evaluating the Associations Among Dysautonomia, Gastrointestinal Transit, and Clinical Phenotype in Patients With Systemic Sclerosis
Authors' conclusion
Symptoms of global dysautonomia are seen in up to one-third of patients with SSc and GI involvement.
Study context
- Population
- Patients with systemic sclerosis (SSc) and gastrointestinal (GI) involvement (mean age 57 years, 90% female, 74% limited cutaneous disease, 83% significant GI disease [Medsger score ≥2])
- Participants
- 91 patients
- Exposure
- Global autonomic dysfunction vs limited autonomic dysfunction
- Outcome
- Dysautonomia burden (COMPASS-31) and its associations with clinical features, GI symptoms and GI transit (whole-gut scintigraphy)
Main finding
As reported in the abstract
Dysautonomia (COMPASS-31)
- Mean COMPASS-31 score, SSc vs controls
- 38.8 vs 7.2
Observational data: associations, not effects.
Further findings
Limited SSc
P < 0.01
Sicca symptoms
P = 0.01
- Gastric and colonic transit · faster in global autonomic dysfunction (GAD)
- P < 0.05
Upper GI involvement (Medsger GI score 1 or 2) and total COMPASS-31 score
- Associated with higher total COMPASS-31 scores (P = 0.02)
Original publication
Evaluating the Associations Among Dysautonomia, Gastrointestinal Transit, and Clinical Phenotype in Patients With Systemic Sclerosis. Arthritis Care Res (Hoboken). Published 10 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →