Systemic sclerosis & Raynaud's
Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype
Authors' conclusion
Distinct clinical features are associated with slow colonic transit in SSc.
Study context
- Population
- Systemic sclerosis (SSc) patients with gastrointestinal symptoms
- Participants
- 100 patients
- Exposure
- SSc patients with vs without slow colonic transit
- Slow colonic transitn = 48
- Outcome
- Clinical features associated with slow colonic transit
Methodological detailsscintigraphy-based whole gut transit study, univariate and multivariable logistic regression
- Scintigraphy-based whole gut transit study
- Univariate and multivariable logistic regression
Main finding
As reported in the abstract
Slow colonic transit
48%
48
- Telangiectasia, multivariable OR
- 3.97 (1.20-13.20) (95% CI)
- Significant restriction on pulmonary function tests, multivariable OR
- 0.28 (0.09-0.86) (95% CI)
- Prior or current smoking, multivariable OR (95% CI) (trend)
- 2.16 (0.82-5.75)
Observational data: associations, not effects.
Further findings
Univariate associations with slow colonic transit
- Female sex, OR
- 12.61 (1.56-101.90) (95% CI)
- Telangiectasia, OR
- 4.00 (1.32-12.10) (95% CI)
- Anticentromere antibodies, OR
- 3.25 (1.25-8.44) (95% CI)
- Prior or current smoking, OR
- 2.56 (1.06-6.21) (95% CI)
- Medsger GI severity score ≥3, OR
- 3.94 (1.16-13.36) (95% CI)
- Significant restriction on pulmonary function tests, OR
- 0.23 (0.09-0.63) (95% CI)
Delayed transit in other GI tract regions
- No significant associations with slow colonic transit
Original publication
Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype. Arthritis Care Res (Hoboken). Published 13 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →