Systemic sclerosis & Raynaud's

Emphysema elevates the DETECT scores: impact on pulmonary hypertension screening and diagnosis in systemic sclerosis

Rheumatology (Oxford)Published Retrospective cohort study

Authors' conclusion

In SSc, CPFE and emphysema are associated with a higher and more frequently positive DETECT score.

Study context

Population
Systemic sclerosis (SSc) patients from a referral centre with chest tomography and data to calculate the DETECT score, without pulmonary hypertension at baseline
Participants
550 eligible cases
Exposure
Combined pulmonary fibrosis and emphysema (CPFE), emphysema and interstitial lung disease (ILD) vs their absence, for DETECT score
  • Emphyseman = 59
  • ILDn = 232
Outcome
DETECT score, DETECT score positivity and false positivity
Follow-up
Baseline
Methodological detailssingle referral centre, regression models adjusted for selected covariates
  • Single referral centre
  • Regression models adjusted for selected covariates

Main finding

As reported in the abstract

DETECT score, positivity and false positivity
GroupValuePrevalence
ILD42%
Emphysema11%
CPFE7%7%

Value

ILD42%
Emphysema11%
CPFE7%

Prevalence

ILD— not stated in the abstract
Emphysema— not stated in the abstract
CPFE7%

Observational data: associations, not effects.

Original publication

Emphysema elevates the DETECT scores: impact on pulmonary hypertension screening and diagnosis in systemic sclerosis. Rheumatology (Oxford). Published 1 August 2025. doi:10.1093/rheumatology/keaf410

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