Systemic sclerosis & Raynaud's
Unveiling the clinical spectrum of ACA-positive SSC-ILD: not as benign as expected
Authors' conclusion
ACA-positive SSc-ILD does not seem to have a more favourable long-term prognosis compared with other serological subsets.
Study context
- Population
- Patients with SSc-ILD by serological subset
- Participants
- 76 / 54 / 147
- Exposure
- ACA-positive SSc-ILD vs ATA-positive and ACA/ATA-negative SSc-ILD
- ACA-positiven = 76
- ATA-positiven = 54
- ACA/ATA-negativen = 147
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Further findings
Time to ILD development · across the three groups
P = 0.389
Lung transplantation
Autologous haematopoietic stem cell transplantation
| Outcome | ACA-positive | ATA-positive | ACA/ATA-negative | P value |
|---|---|---|---|---|
| NYHA class III-IVAcross the three groups | 14.5% | — withheld: not confirmed against the abstract | — withheld: not confirmed against the abstract | P = 0.017 |
| pFVC/pDLCO ratioAcross the three groups | — withheld: not confirmed against the abstract | 1.4 | — withheld: not confirmed against the abstract | P = 0.016 |
| ILD worsening (ATS criteria) | 14.5% | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
— withheld: the automatic checks could not confirm the value against the abstract
- pFVC · across the three groups
- P = 0.013
- pFEV1/pFVC ratio · across the three groups
- P = 0.004
- pKCO · across the three groups
- P = 0.008
- pDLCO · not significant
- P = 0.769
- Overall survival · no significant differences across the three groups
- P = 0.164
Lung transplantation
- No significant differences in antifibrotic indication or advanced interventions
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Unveiling the clinical spectrum of ACA-positive SSC-ILD: not as benign as expected. Rheumatology (Oxford). Published 31 July 2025. doi:10.
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