Systemic sclerosis & Raynaud's
Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology
Authors' conclusion
A higher prevalence of myopathy and interstitial lung disease and a reduced vascular burden were found in the triple-negative patients, suggesting that the non-specific and non-routinely tested autoantibodies may identify an SSc endotype resembling sclero-myositis.
Study context
- Population
- Patients with systemic sclerosis (SSc) in the multicentric Italian SPRING registry
- Participants
- 1,480 patients
- Exposure
- Triple-negative vs SSc-specific antibody-positive SSc
- Triple-negativen = 295
- SSc-specific antibodiesn = 1,185reference
- Outcome
- Prevalence and clinical features of triple-negative SSc
Methodological detailsmulticentre, registry-based
- Multicentre
- Registry-based
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Myopathy
P = 0.003
CPK increase over 2-3 times
P = 0.028
Digital ulcers
P = 0.04
Calcinosis
P = 0.027
DLCO
P = 0.004
Corticosteroid use
P = 0.003
CYC use
P < 0.001
AZA use
P = 0.002
Prostanoid use
P < 0.001
Calcium channel blocker use
P = 0.005
Phosphodiesterase-5 inhibitor use
P < 0.001
CPK levels
P = 0.002
| Outcome | Triple-negative | SSc-specific antibodies | P value |
|---|---|---|---|
| FVC | 97.01% | 102.92% | P < 0.001 |
- ILD
- P < 0.001
ILD
- Higher prevalence of ILD in triple-negative
Original publication
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