Lupus & antiphospholipid syndrome
Efficacy of the Lupus-Cruces Nephritis protocol in different prognostic groups: a propensity score and cluster analysis
Authors' conclusion
The LCN protocol was superior to the SOC schemes in achieving CRR in patients with LN across different subpopulations and clinical clusters.
Study context
- Population
- Patients with LN from the Lupus-Cruces, historic Lupus-Cruces and Lupus-Bordeaux cohorts
- Participants
- 147 patients
- Exposure
- Lupus-Cruces Nephritis (LCN) protocol vs standard of care (SOC)
- LCNn = 47
- SOCn = 100reference
- Outcome
- CRR among different subpopulations and clinical clusters
Methodological detailspropensity score adjusted analysis, Cox proportional hazards analysis, two-way clustering analysis, historic and external cohorts
- Propensity score adjusted analysis
- Cox proportional hazards analysis
- Two-way clustering analysis
- Historic and external cohorts
Main finding
As reported in the abstract
CRR at any time, by clinical cluster (univariate and PS-adjusted Cox regression)
LCN vs SOCHazard ratio (95% CI)P value
Cluster C1
10.7(1.65–69.6)
P = 0.013Cluster C2
2.2(1.16–4.1)
P = 0.016Cluster C3
6.1(2.99–12.51)
P < 0.001Observational data: associations, not effects.
Further findings
CRR, whole cohort · 12 months
Original publication
Efficacy of the Lupus-Cruces Nephritis protocol in different prognostic groups: a propensity score and cluster analysis. Rheumatology (Oxford). Published 22 April 2026. doi:10.
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