Lupus & antiphospholipid syndrome
Long-term efficacy and safety of the Lupus-Cruces Nephritis protocol: a propensity score study of the Lupus-Cruces and Lupus-Bordeaux cohorts
Main finding · CRRResult — go to the resultPS-adjusted HR 3.5 95% CI 2.2–5.5Authors' conclusion
This study confirms the LCN protocol as an effective and safe, in addition to widely available and affordable, regimen for the induction therapy of LN.
Study context
- Population
- Patients with biopsy-proven class III, IV or V lupus nephritis (LN); follow-up up to 10 years
- Participants
- 147 patients
- Exposure
- Lupus-Cruces Nephritis protocol vs standard of care with CYC or mycophenolate
- Lupus-Cruces Nephritis (LCN)n = 47
- Standard of care (SOC)n = 100reference
- Outcome
- Two main outcomes: Complete renal response (CRR) and progression to chronic kidney disease (CKD)
Methodological detailspropensity score-adjusted multivariate analysis, two cohorts (Lupus-Cruces and Lupus-Bordeaux)
- Propensity score-adjusted multivariate analysis
- Two cohorts (Lupus-Cruces and Lupus-Bordeaux)
Main finding
CRR
Propensity score (PS)-adjusted HR
3.5
95% CI 2.2–5.5
P < 0.001
By group
LCNvs SOC
PS-adjusted HR 3.5 (95% CI 2.2–5.5); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | PS-adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Co-main outcome: progression to CKD | 0.3 (0.11–0.82) | P = 0.019 | |
| Renal or GC-related damage accrual | 0.14 (0.04–0.4) | ||
| 0.050.21520PS-adjusted HR (log scale) |
CRR at 12 months
P < 0.001
Safety
| Outcome | Estimate | |
|---|---|---|
| GC-induced toxicity | adjusted HR 0.09 (95% CI 0.02–0.39) | |
| Major infections | PS-adjusted HR 0.2 (95% CI 0.046–0.95) | |
| 0.050.21520Ratio (log scale) |
Original publication
Long-term efficacy and safety of the Lupus-Cruces Nephritis protocol: a propensity score study of the Lupus-Cruces and Lupus-Bordeaux cohorts. Lupus Sci Med. Published 26 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →