Effectiveness of topical sodium thiosulfate for ectopic calcifications and ossifications. Results of the CATSS-O study
Authors' conclusion
Local STS seems effective for ossifications, particularly pediatric calcifications or ossifications.
Study context
- Population
- Patients with ectopic calcifications (ECs) or heterotopic ossifications (HOs) receiving topical sodium thiosulfate (STS) 25 % prepared by the pharmacy of Limoges hospital, 2014–2020; 18 children and 17 adults35 analysed
- Participants
- 126 patients
- Exposure
- ECs vs HOs
- ECsn = 28
- HOsn = 7
- Outcome
- Efficacy of STS assessed by imaging (radiography or CT)
- Follow-up
- After at least 6 months' treatment
Methodological detailssingle-group, CATSS-O registry
- Single-group
- CATSS-O registry
Main finding
As reported in the abstract
Clinical effectiveness of topical STS
- Complete disappearance of calcifications
- 3
Observational data: associations, not effects.
Further findings
Response for ECs, children vs adults (subgroup)
P = 0.035
Original publication
Effectiveness of topical sodium thiosulfate for ectopic calcifications and ossifications. Results of the CATSS-O study. Semin Arthritis Rheum. Published 4 November 2023. doi:10.
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