Systemic sclerosis & Raynaud's
Diffusing capacity of lungs for carbon monoxide associated with subclinical myocardial impairment in systemic sclerosis: A cardiac MR study
Authors' conclusion
DLCO inversely correlates with myocardial native T1 values in SSc patients, particularly moderate-to-severely decreased DLCO, suggesting that DLCO might be a potential indicator for subclinical myocardial impairment in SSc patients.
Study context
- Population
- Patients with systemic sclerosis (SSc) without cardiovascular symptoms and age- and sex-matched healthy subjects
- Participants
- 45 vs 23
- Exposure
- SSc patients without cardiovascular symptoms vs age- and sex-matched healthy subjects; association of lung function (DLCO) with myocardial native T1
- SScn = 45
- Healthyn = 23reference
- Outcome
- Association between lung function (DLCO) and myocardial native T1 values on cardiac MR (CMR)
Methodological detailsage- and sex-matched healthy controls, cardiac MR, Spearman's rank correlations and linear regression
- Age- and sex-matched healthy controls
- Cardiac MR
- Spearman's rank correlations and linear regression
Main finding
As reported in the abstract
Β (unadjusted)
−1.017
95% CI −1.883 to −0.151P = 0.022
DLCO decrease
Β (adjusted for confounding factors)
−1.108
95% CI −2.053 to −0.164P = 0.023
DLCO decrease
Β (adjusted for confounding factors)
48.006
95% CI 17.822–78.190P = 0.003
Moderate-to-severe DLCO decrease
Observational data: associations, not effects.
Further findings
Myocardial native T1 values · considerably higher in SSc
P = 0.006
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →