Systemic sclerosis & Raynaud's
Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function
Authors' conclusion
RIC AHSCT is safe for patients with severe manifestations from SSc. Supplemental oxygen use, elevated BNP, and anti-Scl-70 antibody positivity were risk factors for worse outcomes after RIC AHSCT.
Study context
- Population
- Patients with systemic sclerosis (SSc) and cardiac involvement; 95% with ILD; median % predicted FVC 62% and DLCO 45%
- Participants
- 42 patients
- Outcome
- OS and PFS (progression: reinitiation of DMARDs or worsening end-organ failure)
- Follow-up
- 5 years
Methodological detailssingle-group, Kaplan-Meier, multivariable Cox regression
- Single-group
- Kaplan-Meier
- Multivariable Cox regression
Main finding
As reported in the abstract
5-year overall survival (OS)
75%
95% CI 63%–90%
5-year progression-free survival (PFS)
59%
95% CI 46%–76%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| 5-year OS in participants without supplemental oxygen and BNP <100 pg/mL (subgroup) | No oxygen and BNP <100 pg/mL 91% (95% CI 80%–100%) |
- 5-year OS in participants without supplemental oxygen and BNP <100 pg/mL (subgroup): 24 participants (57%)
Pretransplant factors associated with mortality
- Supplemental oxygen use, HR
- 7.88, P < 0.01
- Elevated BNP, HR per pg/mL
- 1.005, P < 0.01
Pretransplant factor associated with progression
- Anti-Scl-70 antibody positivity, HR
- 3.03, P = 0.02
Original publication
Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function. Arthritis Rheumatol. Published 27 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →