Sjögren's disease & overlap diseases
Diagnostic value of high-frequency ultrasound assessment of the lacrimal glands for primary Sjögren’s disease
Authors' conclusion
LGUS has moderate sensitivity and high specificity for the diagnosis of pSjD.
Study context
- Population
- Patients with suspected primary Sjögren's disease (pSjD) evaluated by salivary gland ultrasound (SGUS) and LGUS as part of the diagnostic set-up; 13 diagnosed with pSjD by ACR/EULAR classification criteria1 excluded (missing data)
- Participants
- 30 patients
- Comparison
- Lacrimal gland US vs salivary gland US for diagnosis of pSjD
- Outcome
- Diagnostic performance of LGUS for pSjD diagnosis (ACR/EULAR classification criteria)
Performance
As reported in the abstract
Diagnostic performance for pSjD
| Test or model | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| LGUS | 61.5 | 87.5 | 80.0 | 73.3 |
LGUS
Sensitivity61.5
Specificity87.5
PPV80.0
NPV73.3
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Association of LGUS with autoantibodiesLGUS | OR (SSA) 17.4 | P = 0.005 |
| Association of LGUS with autoantibodiesLGUS | OR (SSB) 23.0 | P = 0.003 |
Association of LGUS with Schirmer's test positivity
- No statistically significant association
- p value: 0.86
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diagnostic value of high-frequency ultrasound assessment of the lacrimal glands for primary Sjögren’s disease. RMD Open. Published 1 July 2025. doi:10.
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