Spondyloarthritis & psoriatic arthritis
Determinants of radiographic progression in early psoriatic arthritis: insights from a real-world cohort
Authors' conclusion
According to this real-world cohort, patients with early PsA exhibit minimal radiographic progression under current treatment protocols. This study indicates that while old age and initial radiographic damage predict progression, female sex confers a protective effect on it.
Study context
- Population
- Patients with newly diagnosed (early) psoriatic arthritis (PsA), DEPAR (Dutch South West Psoriatic Arthritis) Study1,660 hand and feet radiographs
- Participants
- 476 patients
- Exposure
- Progressive vs non-progressive patients; baseline predictors of radiographic progression
- Progressiven = 71
- Non-progressiven = 405reference
- Outcome
- Radiographic progression over time (mTSS for PsA); baseline predictors
Methodological detailsreal-world cohort, mixed-effects negative binomial regression
- Real-world cohort
- Mixed-effects negative binomial regression
Main finding
As reported in the abstract
Determinants of radiographic change over time (multivariable)
Age, IRR
1.10
p=0.000
Sex (female), IRR
0.48
p=0.043
Baseline mTSS, IRR
1.11
p=0.000
Observational data: associations, not effects.
Further findings
Presence of swollen joints at diagnosis
| Outcome | Progressive | Non-progressive |
|---|---|---|
| Baseline mTSS at diagnosis | 17 (range 3–36) | 0 (range 0–1) |
| Age at diagnosis | 59 (spread 12) | 49 (spread 13) |
Predictors in progressive subset (multivariable)
- Baseline Disease Activity in PSoriatic Arthritis, IRR
- 1.05, p=0.006
- Swollen joint count, IRR
- 1.07, p=0.034
Original publication
Determinants of radiographic progression in early psoriatic arthritis: insights from a real-world cohort. RMD Open. Published 24 May 2024. doi:10.
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