Spondyloarthritis & psoriatic arthritis
Time to improvement of pain, morning stiffness, fatigue, and disease activity in patients with ankylosing spondylitis treated with tofacitinib: a post hoc analysis
Authors' conclusion
Improvements in AS core domains occurred more rapidly with tofacitinib vs. placebo-to-tofacitinib.
Study context
- Population
- Patients with ankylosing spondylitis (AS) in a phase 3 trialassessed
- Participants
- 269 patients
- Comparison
- Tofacitinib 5 mg twice daily vs placebo to W16, then open-label tofacitinib (placebo-to-tofacitinib)
- Tofacitinibn = 133
- Placebo-to-tofacitinibn = 136reference
- Primary endpoint
- Median time to initial (first post-baseline observation) and continued (sustained for 2 consecutive visits) improvement in AS core domains (≥30%/≥50% pain or BASDAI, ASDAS improvement ≥1.1/≥2.0 points)
Methodological detailsplacebo-controlled to W16, open-label tofacitinib W16-48, non-parametric Kaplan-Meier models
- Placebo-controlled to W16
- Open-label tofacitinib W16-48
- Non-parametric Kaplan-Meier models
Primary result
As reported in the abstract
Median time to initial (continued) ≥ 30% pain improvement
Tofacitinib
4
4–8
median · weeks
Placebo-to-tofacitinib
24
24
median · weeks
Further findings
| Outcome | Tofacitinib | Placebo-to-tofacitinib |
|---|---|---|
| Median time to initial (continued) ≥ 50% improvement of pain, peripheral joint pain/swelling and enthesitis, morning stiffness, BASDAI total score, and fatigue | median 8-24 (12-40) weeks | median 24-32 (32-not estimable [NE]) weeks |
| Median time to initial (continued) ASDAS improvement ≥ 1.1 points | median 4 (8) weeks | — not stated in the abstract |
— not stated in the abstract
Median time to AS Disease Activity Score (ASDAS) improvement ≥ 2.0 points
- NE with either treatment
Original publication
Time to improvement of pain, morning stiffness, fatigue, and disease activity in patients with ankylosing spondylitis treated with tofacitinib: a post hoc analysis. Arthritis Res Ther. Published 24 May 2024. doi:10.
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