Spondyloarthritis & psoriatic arthritis
Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development
Main finding · PsA prevalenceResult — go to the resultAdjusted odds ratio 0.228Authors' conclusion
This study provides meaningful and concordant evidence supporting the significant role of different classes of biologics in reducing the likelihood of peripheral and axial PsA development.
Study context
- Population
- Patients with psoriasis (PsO) undergoing rheumatological assessment, single centre
- Participants
- 1,023 patients
- Exposure
- PsO patients treated at least once with biologics vs never treated with biologics
- Outcome
- PsA development (prevalence)
Methodological detailsmonocentric cohort, multivariate logistic regression adjusted for main psoriatic arthritis (PsA) risk factors
- Monocentric cohort
- Multivariate logistic regression adjusted for main PsA risk factors
Main finding
PsA prevalence
Adjusted odds ratio
0.228
P < 0.01
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR | P value |
|---|---|---|
| PsA development, subgroup with PsO onset after 2005 | 0.264 | P < 0.01 |
| PsA development, subgroup with PsO onset after 2014 | 0.179 | P < 0.01 |
| PsA development by biologic classTNFi vs Never biologics | 0.206 | P < 0.01 |
| PsA development by biologic classIL-17i vs Never biologics | 0.051 | P < 0.01 |
| PsA development by biologic classIL-23 or 12/23 inhibitors vs Never biologics | 0.167 | P < 0.01 |
| Prevalence by PsA patternBiologics vs Never biologics · pure peripheral PsA | 0.182 | P < 0.04 |
| Prevalence by PsA patternBiologics vs Never biologics · peripheral PsA with axial involvement | 0.115 | P < 0.04 |
Original publication
Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development. Rheumatology (Oxford). Published 23 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →