Lupus & antiphospholipid syndrome
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis
Authors' conclusion
New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease.
Study context
- Population
- Patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry (RELESSER)1,274 with dated damage events analysed
- Participants
- 4,219 patients
- Outcome
- Organ damage (SLICC/ACR DI, globally and per domain) over time, with emphasis on the cardiovascular system
Methodological detailsmulticentre, registry-based
- Multicentre
- Registry-based
Main finding
As reported in the abstract
Patients with new damage, by year after diagnosis
New damage, first year after diagnosis
20%
New damage, year 2
11%
New damage, year 3
9%
Annual new damage after year 5
5%
Observational data: associations, not effects.
Further findings
Damage by organ system
- First year: most damage in musculoskeletal, neuropsychiatric and renal systems
- Later stages: most damage in musculoskeletal, ocular and cardiovascular systems
Modified cardiovascular domain (incl. cerebrovascular accident and claudication for 6 months)
- Second most affected system in early stages; patients with damage affected at first year
- 19%
- Late stages: patients with new damage in this domain
- 20-25%
Original publication
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis. Lupus Sci Med. Published 3 August 2024. doi:10.
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