Lupus & antiphospholipid syndrome
Severe haematological involvement in children with systemic lupus erythematosus and clinical associations
Authors' conclusion
Severe haematological indices at onset are common but not related with disease outcomes.
Study context
- Population
- Children with SLE with haematological involvement
- Participants
- 224 children
- Outcome
- Severe haematological involvement (AIHA with haemoglobin <8 g/dl, thrombocyte count <30 000/µL, neutrophil count <500/µL)
Methodological detailsmedical chart review
- Medical chart review
Main finding
As reported in the abstract
Severe haematological indices
Severe indices, predominantly at initial involvement
102
45.5%
Severe anaemia
54
24.1%
Severe thrombocytopenia
45
20.1%
Observational data: associations, not effects.
Further findings
Disease activity and damage by severe indices
- Disease activity did not differ according to presence of severe indices
- Severe indices at initial involvement did not affect damage accrual
Damage, flares of haematological system vs no flares
- Damage rate, haematological flares vs no flares (P = 0.002)
- 51.1% vs 29.9%
- Steroid-induced damage, haematological flares vs no flares (P < 0.001)
- 28.9% vs 8.2%
Predictors of haematological system flare (regression)
- RTX during initial episode, OR (P = 0.006)
- 4.5
- aCL antibodies, OR (P = 0.014)
- 2.3
- Severe indices at initial involvement did not increase odds of haematological flare
Original publication
Severe haematological involvement in children with systemic lupus erythematosus and clinical associations. Rheumatology (Oxford). Published 2 August 2024. doi:10.
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