Lupus & antiphospholipid syndrome
Cutaneous vasculitis in systemic lupus erythematosus: epidemiology and risk factors over a 20-year follow-up
Authors' conclusion
The incidence rates of CV in SLE decreased over the follow-up period and CV is associated with defined clinical, serological and treatment-related factors.
Study context
- Population
- SLE patients of the Birmingham Lupus Cohort enrolled within 3 years of meeting their fourth ACR criterion; 95.7% femalemedian follow-up 9.2 years
- Participants
- 392 patients
- Outcome
- Trends and risk factors for cutaneous vasculitis (CV)
- Follow-up
- 20 years
Methodological detailsobservational longitudinal cohort, multivariable shared frailty Cox proportional hazard model
- Observational longitudinal cohort
- Multivariable shared frailty Cox proportional hazard model
Main finding
As reported in the abstract
Cutaneous vasculitis occurrence and incidence rates
Cutaneous vasculitis (CV) occurred in SLE patients
27%
Of those with CV, two or more CV events
43.3%
Incidence rate of CV during first 3 years after enrolment
34.4%
95% CI 29.7, 39.3
Incidence rate of CV after 18 years of follow-up
2.1%
95% CI 0.05, 11.5
Observational data: associations, not effects.
Further findings
- Patients with CV more likely to develop at least one item of organ damage
Original publication
Cutaneous vasculitis in systemic lupus erythematosus: epidemiology and risk factors over a 20-year follow-up. Rheumatology (Oxford). Published 11 December 2024. doi:10.
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