The BILAG-2004 index is associated with development of new damage in SLE

Yee, CS; Gordon, C; Akil, M; Lanyon, P; Edwards, CJ; Isenberg, DA; Rahman, A; Teh, LS; Tosounidou, S; Stevens, R; Prabu, A; Griffiths, B; McHugh, N; Bruce, IN; Ahmad, Y; Khamashta, MA; Farewell, VT

doi:10.1093/rheumatology/keac334

Lupus & antiphospholipid syndrome

The BILAG-2004 index is associated with development of new damage in SLE

Rheumatology (Oxford)Published 10 Jun 2022Prospective cohort study

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Authors' conclusion

BILAG-2004 index is associated with new damage.

Study context

Population: SLE patients recruited within 12 months of achieving fourth ACR classification criterion, 2005–2017
Participants: 273 patients1,767 patient-years

Outcome: Development of new damage (association with BILAG-2004 index)

Methodological detailsmulticentre, longitudinal, Poisson regression

Multicentre
Longitudinal
Poisson regression

Main finding

As reported in the abstract

Damage accrual

Overall rate for damage accrual, per 1000 person-years

61.1

95% CI 50.6, 73.8

New damage items (in 83 patients)

114

Observational data: associations, not effects.

Further findings

Mortality

Deaths during follow-up: 13

Reference

Authors: Yee CS, Gordon C, Akil M, Lanyon P, Edwards CJ, Isenberg DA, et al.
All 17 authors
Yee CS, Gordon C, Akil M, Lanyon P, Edwards CJ, Isenberg DA, Rahman A, Teh LS, Tosounidou S, Stevens R, Prabu A, Griffiths B, McHugh N, Bruce IN, Ahmad Y, Khamashta MA, Farewell VT
Journal: Rheumatology (Oxford)
Published: 10 Jun 2022
DOI: 10.1093/rheumatology/keac334
PubMed: 35686924

Topic: Lupus & antiphospholipid syndrome

Key notes

Active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage
Low disease activity states (BILAG-2004 low disease activity (LDA) and BILAG Systems Tally (BST) persistent LDA) were inversely associated with development of damage

More notes

Incidence rate of damage higher in the first 3 years before stabilizing at a lower rate

Original publication

The BILAG-2004 index is associated with development of new damage in SLE. Rheumatology (Oxford). Published 10 June 2022. doi:10.1093/rheumatology/keac334

Read the original article ↗

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