Lupus & antiphospholipid syndrome
Trajectories of depressive symptoms in systemic lupus erythematosus over time
Authors' conclusion
Four classes of depressive symptoms were identified in patients with SLE.
Study context
- Population
- Individuals with SLE in the Lupus Outcomes Study, University of California, San Francisco
- Participants
- 763 individuals
- Exposure
- Class 1 vs Class 2 vs Class 3 vs Class 4
- Outcome
- Trajectories (latent classes) of depressive symptoms by CES-D score, years two through seven
- Follow-up
- 6 years
Methodological detailsgroup-based trajectory modelling, ordinal logistic regression
- Group-based trajectory modelling
- Ordinal logistic regression
Main finding
As reported in the abstract
Trajectory classes of CES-D scores
Observational data: associations, not effects.
Further findings
Baseline characteristics associated with membership in worse classes of depressive symptoms
- Greater age, OR
- 0.97 (0.96, 0.99) (95% CI)
- Higher education level, OR
- 0.79 (0.70, 0.89) (95% CI)
- Lower income, OR
- 1.73 (1.03, 2.92) (95% CI)
- Worse SF-36 physical functioning scores, OR
- 1.12 (1.12, 1.13) (95% CI)
- Worse SF-36 bodily pain scores, OR
- 1.58 (1.55, 1.61) (95% CI)
Original publication
Trajectories of depressive symptoms in systemic lupus erythematosus over time. Rheumatology (Oxford). Published 10 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →