Lupus & antiphospholipid syndrome
Cost-of-illness changes before and after the diagnosis of systemic lupus erythematosus: a nationwide, population-based observational study in Korea
Main finding · Annual direct healthcare costs per personResult — go to the resultFold greater 7.7Authors' conclusion
Patients with SLE incurred significantly higher direct healthcare costs than subjects without SLE during the first year after diagnosis. Disease severity, older age, major organ involvements and comorbidities were associated with increased healthcare costs.
Study context
- Population
- Patients with incident systemic lupus erythematosus (SLE) diagnosed 2008–2018, Korean National Health Insurance database, and matched controlsmatched cohort
- Participants
- 11,173 vs 45,500
- Exposure
- Incident SLE vs matched controls without SLE; severe vs mild SLE
- SLEn = 11,173
- Without SLEn = 45,500reference
- Outcome
- Annual direct healthcare costs per person, 5 years before and after SLE diagnosis
Methodological detailsnationwide, age-, sex- and calendar month-matched (1:4) controls, regression analysis
- Nationwide
- Age-, sex- and calendar month-matched (1:4) controls
- Regression analysis
Main finding
Annual direct healthcare costs per person · first year after diagnosis
Fold greater
7.7
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Fold higher annual costs (95% CI) |
|---|---|
| Annual costs, severe vs mild SLE · year after diagnosis | 3.284 (3.075–3.507) |
Factors associated with higher annual direct healthcare costs (times) · first year after diagnosis
- Age 60-69
- 1.119 (1.034, 1.211)
- Age 70-79
- 1.470 (1.342, 1.611)
- LN
- 1.794 (1.711, 1.881)
- ILD
- 1.435 (1.258, 1.638)
- Avascular necrosis
- 6.208 (4.541, 8.487)
- CKD
- 1.858 (1.673, 2.064)
- 95% CI
Original publication
Cost-of-illness changes before and after the diagnosis of systemic lupus erythematosus: a nationwide, population-based observational study in Korea. Rheumatology (Oxford). Published 9 December 2023. doi:10.
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