Lupus & antiphospholipid syndrome
Immunohistochemical expression of perforin in adult systemic lupus erythematosus associated macrophage activation syndrome: Clinicohematological correlation and literature review
Authors' conclusion
We noted a decrease in perforin mediated CD8 + T cell cytotoxicity in SLE.
Study context
- Population
- Cytopenic adult systemic lupus erythematosus (SLE) cases with bone marrow (BM) trephine biopsies (male: female = 1:5, age 24 years, range 19–32)plus ten age matched controls
- Participants
- 30 cases
- Exposure
- SLE cases likely (MAS-L) vs unlikely (MAS-U) to have MAS; SLE cases vs age matched controls
- MAS-Ln = 12
- Controlsn = 10
- Outcome
- BM immunohistomorphological characteristics (immunohistochemical (IHC) expression of CD3, CD8, perforin, CD163) in SLE-MAS
Methodological detailsage matched controls, probability scoring criteria, ROC analysis
- Age matched controls
- Probability scoring criteria
- ROC analysis
Main finding
As reported in the abstract
| Group | Value | MAS score |
|---|---|---|
| MAS-L | 40% | 185 (176-203) |
| MAS-U | 105 (77-119) |
Value
MAS-L40%
MAS-U— not stated in the abstract
MAS score
MAS-L185 (176-203)
MAS-U105 (77-119)
- MAS-L vs MAS-U: P < 0.01
- MAS-L vs MAS-U: P < 0.01
- MAS-L vs MAS-U: P = 0.002
- MAS-L vs MAS-U: P = 0.002
- MAS-L vs MAS-U: P = 0.07
- MAS-L vs MAS-U: P = 0.09
Observational data: associations, not effects.
Further findings
Discrimination of MAS from no MAS (ROC)
- Fibrinogen < 2.4 g/L, AUC (p < .01)
- 0.93
- Hemophagocytosis score > 1.5, AUC (p = .03)
- 0.71
- MAS probability score ≥ 164, AUC (p < .01)
- 1
Original publication
Immunohistochemical expression of perforin in adult systemic lupus erythematosus associated macrophage activation syndrome: Clinicohematological correlation and literature review. Lupus. Published 8 December 2023. doi:10.
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