Correlation Between Interferon Response Gene Score and Disease Activity in Juvenile Dermatomyositis
Authors' conclusion
This study shows evidence of a significant correlation between IRG score and disease activity, which is maintained over time.
Study context
- Population
- Patients with juvenile dermatomyositis (JDM) enrolled in the Childhood Arthritis and Rheumatic Diseases (CARD) biobank at The Hospital for Sick Children (SickKids), Toronto, Canada, January 2015 to June 202287 biosamples
- Participants
- 43 patients
- Outcome
- Correlation between disease activity (modified Disease Activity Score) and NanoString IRG score, early in the disease course and longitudinally
Methodological detailssingle-centre, biobank, longitudinal, linear mixed model regression
- Single-centre
- Biobank
- Longitudinal
- Linear mixed model regression
Main finding
As reported in the abstract
Correlation of IRG score with disease activity · Enrollment visit
Spearman correlation at enrollment visit, all subjects (rs)
0.78
Spearman correlation at enrollment visit, treatment-naïve cohort (rs)
0.63
Observational data: associations, not effects.
Further findings
Longitudinal association of IFN response gene (IRG) score with disease activity, treatment-naïve cohort (linear mixed model) · Over time
- β coefficient for IRG score (P < 0.001)
- 0.004
Original publication
Correlation Between Interferon Response Gene Score and Disease Activity in Juvenile Dermatomyositis. J Rheumatol. Published 15 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →