Clinically suspect arthralgia patients with a low educational attainment have an increased risk of developing inflammatory arthritis
Main finding · IA developmentResult — go to the resultHazard ratio 2.35 95% CI 1.27–4.33Authors' conclusion
This is the first study providing evidence that lower educational attainment is associated with a higher risk of progressing from arthralgia to IA. This effect was partially mediated by subclinical joint inflammation.
Study context
- Population
- Consecutive patients presenting with clinically suspect arthralgia (CSA)
- Participants
- 521 patients
- Exposure
- Low vs intermediate or high educational attainment
- Outcome
- Development of inflammatory arthritis (IA)
- Follow-up
- Median 25 months
Methodological detailsconsecutive patients, Cox regression, mediation analysis, independent validation cohort
- Consecutive patients
- Cox regression
- Mediation analysis
- Independent validation cohort
Main finding
IA development
Hazard ratio
2.35
95% CI 1.27–4.33
P = 0.006
Low
HR 2.35 (95% CI 1.27–4.33); P = 0.006
As reported in the abstract
Observational data: associations, not effects.
Further findings
Inflammatory arthritis (IA) development, validation cohort
| HR (95% CI) | P value | ||
|---|---|---|---|
| Low | 5.72 (1.36–24.08) | P = 0.017 | |
| 0.050.21520Hazard ratio (log scale) |
Subclinical joint inflammation (MRI) as mediator
- Low educational attainment had higher levels of subclinical inflammation, which was also associated with IA development
- Partial mediation effect of subclinical inflammation
Original publication
Clinically suspect arthralgia patients with a low educational attainment have an increased risk of developing inflammatory arthritis. Rheumatology (Oxford). Published 3 August 2022. doi:10.
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