Global, regional and national burden of rheumatoid arthritis, and attributable risk factors from 1990 to 2019: update from the Global Burden of Disease 2019 study
Authors' conclusion
The incidence rate of RA and associated DALYs are increasing worldwide, particularly among female patients.
Study context
- Population
- Rheumatoid arthritis (RA) in 204 territories and countries, Global Burden of Disease (GBD) 2019, 1990–2019204 countries and territories
- Outcome
- RA incidence, ASR, DALYs and EAPC
- Follow-up
- 1990–2019
Methodological detailsGBD 2019 secondary data analysis, 204 countries and territories, comparative risk assessment framework
- GBD 2019 secondary data analysis
- 204 countries and territories
- Comparative risk assessment framework
Main finding
As reported in the abstract
RA incidence (cases) · 1990 to 2019
ASR, 1990–2019
13/100,000
Observational data: associations, not effects.
Further findings
Association between Estimated Annual Percentage Change (EAPCs) and age-standardised Disability-adjusted Life Years (DALYs) per 100,000
- Significant negative association (ρ; p<0.001)
- −0.60
Sex differences
- Females had higher ASRs and DALYs than males, globally and regionally
Age-standardised DALYs by age
- Increased with age; highest in 60-69 years age group
Risk factors for RA-associated DALYs · 1990 to 2019
- Smoking predominant contributor in males worldwide; trend decreased from 1990 to 2019
Original publication
Global, regional and national burden of rheumatoid arthritis, and attributable risk factors from 1990 to 2019: update from the Global Burden of Disease 2019 study. Clin Exp Rheumatol. Published 30 July 2022. doi:10.
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