Lupus & antiphospholipid syndrome
Clinical features of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuritis associated with SLE
Authors' conclusion
SLE-associated GBS/CIDP may manifest regardless of disease systemic activity. Clinical features may differ from that of pure GBS/CIDP, and treatment often requires immunosuppressants, making differential diagnosis crucial, especially for patients with GBS/CIDP presenting as the first manifestation of SLE.
Study context
- Population
- Patients at Peking Union Medical College Hospital, January 2004–November 2021, fulfilling diagnostic criteria for SLE and Guillain-Barré syndrome (GBS)/chronic inflammatory demyelinating polyradiculoneuritis (CIDP)
- Participants
- 9 patients
- Exposure
- SLE and GBS vs SLE and CIDP
- SLE and GBSn = 6
- SLE and CIDPn = 3
- Outcome
- Clinical features, treatments and outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Age at diagnosis, average
- 38.6±18.2 years
- SLE disease duration range
- 1 week to 36 years
- GBS course range
- 1 week to 2 months
- CIDP course range
- 2 months to 15 months
- CSF white blood cell count, median (range)
- 0.002×109/L (0-0.006×109/L)
- CSF protein, median (range)
- 0.79 g/L (0.57-7.09 g/L)
- Received CYC
- 7
- Received intrathecal MTX and dexamethasone
- 7
- Complete resolution
- 2
- Marked improvement
- 5
- Failed to improve
- 2
Observational data: associations, not effects.
Original publication
Clinical features of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuritis associated with SLE. Lupus Sci Med. Published 10 October 2024. doi:10.
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