Autoinflammatory & rare systemic diseases
Clinical characteristics of obese patients with adult-onset Still's disease. Data from a large multicentre cohort
Authors' conclusion
Obese patients at the time of diagnosis of the disease were characterised by a lower prevalence of sore throat, serositis, as well as by higher values of CRP and ferritin. Obesity was also a predictive factor for a chronic disease course and bDMARD failure
Study context
- Population
- Adult-onset Still's disease (AOSD) patients with body mass index (BMI) registered in the multicentre GIRRCS cohort (Italy)BMI registered
- Participants
- 139 patients
- Exposure
- Obese vs non-obese AOSD patients
- Obesen = 26
- Outcome
- Clinical features and outcomes of obese vs non-obese AOSD
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Obese
18.7%
26
- Lower rate of sore throat in obese patients
- P < 0.05
- Lower rate of pericarditis in obese patients
- P < 0.05
- Lower rate of pleuritis in obese patients
- P < 0.05
- Higher C-reactive protein (CRP) in obese patients
- P < 0.05
- Higher ferritin in obese patients
- P < 0.05
- Biologic disease-modifying antirheumatic drug (bDMARD) failure in subsequent follow-up in obese patients
- P < 0.05
- Higher rate of comorbidity in obese vs non-obese patients
- P < 0.05
Observational data: associations, not effects.
Further findings
Chronic disease course (obesity as predictor)
| HR (95% CI) | P value | ||
|---|---|---|---|
| ObesityUnivariate analysis | 1.72 (1.03–2.51) | P < 0.05 | |
| ObesityMultivariate analysis | 1.85 (1.45–2.89) | P < 0.05 | |
| 0.20.5125Hazard ratio (log scale) |
bDMARD failure (obesity as predictor)
| HR (95% CI) | P value | ||
|---|---|---|---|
| ObesityUnivariate analysis | 3.03 (1.42–6.45) | P < 0.01 | |
| ObesityMultivariate analysis | 3.59 (1.55–8.27) | P < 0.01 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Clinical characteristics of obese patients with adult-onset Still's disease. Data from a large multicentre cohort. Joint Bone Spine. Published 18 April 2023. doi:10.
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