Autoinflammatory & rare systemic diseases
Sarcoidosis rates in Bacille Calmette-Guérin (BCG)-vaccinated and unvaccinated young adults: A natural experiment using Danish registers
Authors' conclusion
In this quasi-experimental study that minimizes confounding, the time period with high BCG vaccine uptake was associated with a lower incidence rate of sarcoidosis in men, with a similar effect seen in women that did not reach significance.
Study context
- Population
- Danish individuals aged 25–35 years born 1970–1981; Danish Civil Registration System and National Patient Registry, 1995–2016
- Exposure
- Born during low BCG vaccine uptake vs high BCG vaccine uptake
- Outcome
- Incidence rate of sarcoidosis (IRR)
Methodological detailsquasi-randomized, natural experiment, Poisson regression adjusted for age and calendar year, separate analyses for men and women
- Quasi-randomized
- Natural experiment
- Poisson regression adjusted for age and calendar year
- Separate analyses for men and women
Main finding
As reported in the abstract
Sarcoidosis incidence, by sex
Low BCG uptake vs High BCG uptakeIncidence rate ratio (95% CI)
Men
1.22(1.02–1.45)
Women
1.08(0.88–1.31)
Observational data: associations, not effects.
Original publication
Sarcoidosis rates in BCG-vaccinated and unvaccinated young adults: A natural experiment using Danish registers. Semin Arthritis Rheum. Published 6 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →