Children systemic lupus erythematosus-associated pancreatitis
Authors' conclusion
CSLE-associated pancreatitis has a high fatality rate.
Study context
- Population
- Children with SLE-associated pancreatitis diagnosed and treated January 2016 to December 2021 at hospitals such as Children's Hospital of Capital Institute of Paediatrics12 cases
- Comparison
- Children systemic lupus erythematosus (cSLE)-associated pancreatitis vs control
- Casen = 12
- Outcome
- SLEDAI-2K disease activity score
Main finding
As reported in the abstract
Case
18.00
median · range 12.25–21.00
Control
10.00
median · range 7.00–18.00
P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Clinical features | P < 0.05 |
| Laboratory findings | P < 0.05 |
| Treatment | P < 0.05 |
Clinical features
- Higher proportion of abdominal pain, vomiting, abdominal distension, pleural effusion, Raynaud's phenomenon (RP), splenic infarction and concurrent macrophage activation syndrome (MAS) in cases than controls
Laboratory findings
- Serum ferritin, alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), amylase, increased 24-h urine protein and PLT reduction differed between groups
Treatment
- Higher proportion of methylprednisolone pulse, CYC pulse during remission induction and therapeutic plasma exchange in cases than controls
Original publication
Children systemic lupus erythematosus-associated pancreatitis. Arthritis Res Ther. Published 17 January 2024. doi:10.
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