Rhupus syndrome in children: A multi-center retrospective cohort study and literature review
Authors' conclusion
Most of the pediatric patients had polyarticular, asymmetric, and erosive arthritis, as well as organ involvements associated with SLE, including the skin, hematological system, and kidney.
Study context
- Population
- Pediatric patients with rhupus syndrome, 12 centres in Turkey, plus pediatric cases from the literature30 cohort
- Outcome
- Characteristics of pediatric rhupus
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Cohort: Juvenile idiopathic arthritis (JIA) phenotype at disease onset
- 60%
- Cohort: SLE phenotype at last visit
- 73.3%
- Cohort: skin involvement
- 80%
- Cohort: hematological involvement
- 53.3%
- Cohort: kidney involvement
- 23.3%
- Cohort: polyarticular arthritis
- 73.3%
- Cohort: asymmetric arthritis
- 66.7%
- Cohort: erosive arthritis
- 53.3%
- Cohort, SLE treatment: HCQ
- 100%
- Cohort, SLE treatment: GC
- 86.7%
- Cohort, SLE treatment: MMF
- 46.7%
- Cohort, JIA treatment: GC
- 76.6%
- Cohort, JIA treatment: MTX
- 73.3%
- Cohort, JIA treatment: Nonsteroidal anti-inflammatory drugs (NSAIDs)
- 57.6%
- Literature: RF positive
- 75%
- Literature: JIA phenotype at disease onset
- 91.7%
- Literature: SLE phenotype at last visit
- 63.6%
- Literature: skin involvement
- 66.7%
- Literature: hematological involvement
- 58.3%
- Literature: kidney involvement
- 58.3%
- Literature: polyarticular arthritis
- 77.8%
- Literature: asymmetric arthritis
- 63.6%
- Literature: erosive arthritis
- 83.3%
- Literature, SLE treatment: GC
- 100%
- Literature, SLE treatment: HCQ
- 76.9%
- Literature, SLE treatment: AZA
- 46.2%
- Literature, JIA treatment: MTX
- 76.9%
- Literature, JIA treatment: NSAIDs
- 46.2%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Rhupus syndrome in children: A multi-center retrospective cohort study and literature review. Lupus. Published 16 January 2024. doi:10.
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