Sjögren's disease & overlap diseases
Characterisation of crevicular fluid microbiota in primary Sjögren's syndrome
Authors' conclusion
The crevicular fluid microbiota of pSS patients and controls differed significantly, even in SSP patients depending on their serology, parotid gland enlargement, and periodontal disease status.
Study context
- Population
- Primary Sjögren's syndrome (pSS) patients without diabetes mellitus, active neoplasia, recent antibiotic use or active infection
- Participants
- 48 vs 17
- Exposure
- pSS vs sex- and age-matched controls
- pSSn = 48
- Controlsn = 17reference
- Outcome
- Taxonomy of the crevicular fluid microbiota
Methodological detailssex- and age-matched controls, 16SrRNA V3-V4 sequencing
- Sex- and age-matched controls
- 16SrRNA V3-V4 sequencing
Main finding
As reported in the abstract
Crevicular fluid microbiota taxonomy
- pSS had more Prevotella, Streptococcus, Veillonella, Fusobacterium and Leptotrichia and fewer Selenomonas than controls
- pSS microbiota contained more genes encoding accessory secretory proteins
Observational data: associations, not effects.
Further findings
Microbiota by clinical/serological variables in pSS
- Microbiota differed by anti-Ro/La status, parotid gland enlargement and periodontal disease severity
- Microbiota did not correlate with non-stimulated whole salivary flow (NSWSF) and XeQoLS
Original publication
Characterisation of crevicular fluid microbiota in primary Sjögren's syndrome. Clin Exp Rheumatol. Published 18 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →