Cardiovascular risk and cardiac involvement in idiopathic inflammatory myopathies: insights from a cross-sectional Swedish single-centre study
Authors' conclusion
Cardiovascular complications in patients with IIM may result from an increased prevalence of traditional cardiovascular risk factors, such as higher BMI, diabetes mellitus, and dyslipidaemia, and/or from direct cardiac involvement, such as previous myocarditis. Cardiac involvement in IIM is notably associated with the IMNM subtype.
Study context
- Population
- Patients with IIM and age- and gender-matched healthy controls, Swedish single centre; ECG, transthoracic echocardiography, cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP)
- Exposure
- IIM patients vs age- and gender-matched healthy controls; IIM with vs without previous cardiac involvement
- IIMn = 109
- Healthy controlsn = 20reference
- Outcome
- Cardiovascular profile, including risk factors and cardiovascular abnormalities
Methodological detailssingle-centre, age- and gender-matched healthy controls
- Single-centre
- Age- and gender-matched healthy controls
Main finding
As reported in the abstract
- IIM vs Healthy controls: P = 0.023
- IIM vs Healthy controls: P = 0.024
- IIM vs Healthy controls: P = 0.042
- IIM vs Healthy controls: P = 0.041
- IIM vs Healthy controls: P = 0.004
- IIM vs Healthy controls: P = 0.041
- IIM vs Healthy controls: P = 0.012
- IIM vs Healthy controls: P = 0.034
Observational data: associations, not effects.
Further findings
| Outcome | IIM with previous cardiac involvement | IIM without cardiac involvement | P value |
|---|---|---|---|
| IMNM subtype proportion, IIM with vs without previous cardiac involvement | 50% | 20% | P = 0.037 |
- cTnI levels (higher with cardiac involvement) · IIM with previous cardiac involvement vs IIM without cardiac involvement
- P = 0.009
Original publication
Cardiovascular risk and cardiac involvement in idiopathic inflammatory myopathies: insights from a cross-sectional Swedish single-centre study. Scand J Rheumatol. Published 13 March 2025. doi:10.
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