Myocarditis in anti-synthetase syndrome: clinical features and diagnostic modalities
Authors' conclusion
In ASS, myocarditis is frequent, even at clinical onset. Patients with ASS with myocarditis frequently presented with fever and increased CRP, suggesting the existence of an inflammatory phenotype.
Study context
- Population
- Patients with anti-synthetase syndrome (ASS)median age 58 years
- Participants
- 43 patients
- Exposure
- ASS with myocarditis vs ASS without myocarditis; 2018 vs 2009 Lake Louise criteria
- Myocarditisn = 13
- Outcome
- Frequency and clinical and CMRI features of myocarditis in ASS
Main finding
As reported in the abstract
Myocarditis diagnosed
Myocarditis
30%
13
- Myocarditis diagnosed at clinical onset
- 54%
- Increased extracellular volume (ECV) on cardiac MRI (CMRI) in myocarditis
- all cases
- Late gadolinium enhancement (LGE) on CMRI in myocarditis
- 91%
- Increased T1 and T2 mapping in myocarditis
- 91%
- Sensitivity: 2009 Lake Louise criteria (LLC) vs 2018 LLC
- 54.6% to 91.0%
Observational data: associations, not effects.
Further findings
Male sex
P = 0.009
Fever
P = 0.001
hs-TnT
P < 0.001
NT-proBNP
P = 0.013
CRP
P = 0.011
Original publication
Myocarditis in anti-synthetase syndrome: clinical features and diagnostic modalities. Rheumatology (Oxford). Published 5 October 2023. doi:10.
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