Prevalence and early detection of myocarditis in idiopathic inflammatory myopathies: a prospective single-centre study
Authors' conclusion
Myocarditis occurred in 27% of this cohort, with IIM/SSc overlap being the most common subgroup.
Study context
- Population
- Patients with newly diagnosed idiopathic inflammatory myopathy (IIM), Johns Hopkins Myositis Center, 7/1/2022–3/30/2023
- Participants
- 26 patients
- Exposure
- IIM with vs without myocarditis
- Myocarditisn = 7
- Outcome
- Prevalence of myocarditis (CMR, 2009 Lake Louise Criteria)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Myocarditis by CMR (Lake Louise Criteria)
Prevalence of myocarditis
27%
7/26
Observational data: associations, not effects.
Further findings
Elevation of both troponin and NT-proBNP
P = 0.003
Abnormal ECG
P = 0.004
| Outcome | Myocarditis | Without myocarditis |
|---|---|---|
| Reduced ejection fraction (EF <50%) on echocardiogramPoor sensitivity | 29% | — not stated in the abstract |
— not stated in the abstract
- Symptomatic (dyspnoea on exertion, pleuritic chest pain or palpitations) among those with myocarditis
- 71% · 5 of 7
IIM/SSc overlap (most common diagnosis) and anti-Ku (most common antibody) among those with myocarditis
- IIM/SSc overlap
- 5/7, 71%
- Anti-Ku
- 3/7, 43%
Original publication
Prevalence and early detection of myocarditis in idiopathic inflammatory myopathies: a prospective single-centre study. Clin Exp Rheumatol. Published 29 March 2025. doi:10.
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