Myocarditis in Patients With Idiopathic Inflammatory Myopathies: Clinical Presentation and Outcomes
Authors' conclusion
Clinical presentations of myocarditis in this select cohort of patients with IIM were severe and heterogeneous with poor outcomes despite intensification of immunosuppression, potentially reflecting late detection of myocarditis.
Study context
- Population
- Adults with IIM and clinical myocarditis, Johns Hopkins Myositis Center Research Registry, 2004–202131 with myocarditis code screened
- Participants
- 14 adults
- Outcome
- Clinical phenotype and outcomes of patients with IIM and myocarditis
Methodological detailssingle-centre registry
- Single-centre registry
Main finding
As reported in the abstract
- Median age at IIM diagnosis, years (IQR 35-56)
- 49
- Median age at myocarditis diagnosis, years (IQR 36-61)
- 54
- Median duration between IIM diagnosis and myocarditis, years (IQR 2-9)
- 3
- Female, 8/14
- 57%
- Black, 10/14
- 71%
- ASyS (most common IIM subtype), 9/14
- 64%
- Anti-Jo1, n
- 4
- Anti-PL12, n
- 3
- Active myositis at myocarditis diagnosis, 11/14
- 79%
- Hospitalization required, 13/14
- 93%
- Reduced LVEF (<50%) at myocarditis diagnosis, 10/14
- 71%
- 5-year overall survival from IIM diagnosis
- 84%
- 5-year overall survival from myocarditis diagnosis
- 53%
- Systolic dysfunction (LVEF <40%) at final evaluation in all expired patients, n
- 6
Observational data: associations, not effects.
Original publication
Myocarditis in Patients With Idiopathic Inflammatory Myopathies: Clinical Presentation and Outcomes. J Rheumatol. Published 1 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →